The glass bottle packaging market for the most gun

2022-08-06
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The pharmaceutical glass bottle packaging market is becoming smaller

there are three kinds of packaging for glucose injection for infusion of patients: glass bottle, plastic bottle and infusion bag. Comparison of their properties (i.e. biological, chemical and physical properties of glucose injection): glass bottle is the best, plastic bottle is the second, and infusion bag is the worst. Comparison of their prices: glass bottle is the lowest, plastic bottle is more than 2 times of glass bottle, and infusion bag is more than 3 times of glass bottle. At present, the market of glass bottle packaging is becoming smaller and the market of plastic bottle and infusion bag packaging is becoming larger. Why? What to do

attachment: comparison of large infusion performance of glass bottle, plastic bottle and infusion bag take glucose and sodium chloride injection as an example

I. large infusion before dispensing

notes: 1. Large infusion filling is hot filling, and negative pressure is generated in the closed bottle after hot filling. If there is no negative pressure in the large infusion of glass bottle, it is prohibited to use

2. The plastic bottle and infusion bag have air permeability and water permeability (especially the infusion bag), and there is no negative pressure inside

2.1 plastic bottles and infusion bags should not be used in the storage environment with high humidity or toxic and corrosive gases

2.2 plastic bottles and infusion bags with pollution or corrosion marks outside the bottle and bag shall not be used

3. When plastic bottles and infusion bags are formed, there are many particles falling off (especially the infusion bags), which should be checked in the bright place during use. If the clarity is affected, it is forbidden to use

4. PVC infusion bags may release toxic substances at high temperature, which should be paid attention to

glass bottle: biological performance/microbial pyrogen free

chemical performance/pH value 3.8 5.0 heavy metal 0.3ppm other

physical performance/particle 10um 10/ml absorbance 0.10 clarity

plastic bottle: biological performance/microbial pyrogen free

chemical performance/pH value 3.6 5.3 heavy metal 0.5ppm other

physical performance/particle 10um 19/ml absorbance 0.25 clarity

infusion bag: raw Physical properties/microbial pyrogen free

chemical properties/pH value 3.5 5.5 heavy metals 0.5ppm other

physical properties/particles 10um 20 particles/ml absorbance 0.25 clarity second

conclusion: 1. In line with the provisions of the Pharmacopoeia

2. Glass bottle had the least effect on the drug solution

3. Plastic bottles and infusion bags have water permeability, gas permeability and many falling particles (especially infusion bags), which will affect the quality of large infusion

II. Large infusion after dispensing

Description: 1. Standardized dispensing with dosing device

2. Syringe dispensing, dispensing operation has a great impact on the infusion performance of large high-strength bolt test fixture, mainly tensile test fixture and wedge load test fixture (especially when used for large infusion of infusion bag), and its performance is not comparable, so it will not be compared here

glass bottle: biological performance/microorganism 01/bottle pyrogen free

chemical performance/pH value 3.8 5.0 heavy metal 0.3ppm other

physical performance/particle 10um 10 particles/ml absorbance 0.10 clarity

plastic bottle: biological performance/microorganism 01/bottle pyrogen free

chemical performance/pH value 3.6 5.3 heavy metal 0.5ppm other

physical performance/particle 10um 19 particles/ml absorbance 0.25 clarity second

Infusion bag: biological performance/microorganism 02/bottle pyrogen free

chemical performance/pH value 3.5 5.5 heavy metal 0.5ppm other

physical performance/particle 10um 20 particles/ml absorbance 0.25 clarity second

conclusion: 1. The dispensing operation will pollute the drug solution

2. Large infusion bags are most likely to be contaminated by dispensing operations

III. after infusion (the situation of the liquid medicine entering the human body)

notes: 1. Glass bottles and plastic bottles are different from large infusion bags. During infusion, external air needs to enter the bottle from the exhaust pipe of the infusion set, and the liquid medicine in the bottle will be polluted by foreign matters in the air again

1.1 foreign matters in the air of normal environment (such as general ward) include living microorganisms and particles. The air is filtered through the air filter in the exhaust pipe on the infusion set, and the air becomes purified air. The cleanliness is above 100000. 20 particles larger than 0.5um/l and 0.5 live microorganisms/l are in the purified gas

1.2 in some special environments (such as some respiratory infectious disease wards, in the environment with large pollution such as oil smoke or toxic and corrosive gases), abnormal air is filtered through the air filter in the exhaust pipe on the infusion set, and there are still some substances that affect the performance of the liquid medicine, so the liquid transmission should be avoided as far as possible, or the external liquid bag with excellent heat insulation performance should be selected for large-scale infusion without air intake from the exhaust pipe

2. Select the infusion set, and the aperture of the air filter on it should be less than 0.45um, preferably less than 0.1um, so that bacteria and viruses can be completely filtered out

glass bottle: biological performance/microorganism 02/bottle pyrogen free

chemical performance/pH value 3.8 5.0 heavy metal 0.3ppm other

physical performance/particle 10um 10+0.1 particle/ml absorbance 0.10 clarity

plastic bottle: biological performance/microorganism 02/bottle pyrogen free

chemical performance/pH value 3.6 5.3 heavy metal 0.5ppm other

physical performance/particle 10um 19+0.1 particle/ml absorbance 0.25 clarity takes the second place

infusion bag: biological performance/microorganism 0.2/bottle pyrogen free

chemical performance/pH value 3.5 5 5.5 heavy metal 0.5ppm other

physical performance/particle 10um 20 particles/ml absorbance 0.25 clarity second

conclusion: 1. Air enters the liquid medicine in glass bottles and plastic bottles through the air filter in the exhaust pipe of the infusion set, which will affect the quality of the liquid medicine. Otherwise, it will affect the results of the experiment. The impact depends on the environment

2. In the normal environment, large glass bottle infusion is selected, and the drug solution entering the human body has the best performance

author's note: there are some problems in the quality of the traditional glass bottle large infusion bottle stopper and the plastic film under it, which need to be improved, and the improvement will increase the cost. Because the price of large infusion of glass bottle is too low, it is not cost-effective for the manufacturer to improve the bottle stopper and plastic film alone, so the manufacturer changed the whole large infusion package to plastic bottle and infusion bag. The price of large infusion of plastic bottle and infusion bag is much higher, and the manufacturer is cost-effective and worth it

plastic bottles and infusion bags will have a new impact on the quality of large infusion. After all, most screws will be pushed out of the barrel, resulting in new problems. In fact, the performance indicators of large infusion of plastic bottles and infusion bags are worse than those of glass bottles

poor performance, high pricing and better economic benefits; Good performance. Due to the early pricing time, modern quotation materials cannot be made. The lower the pricing, the worse the economic benefit. Is this reasonable

there is a problem with the price system of drugs

the pricing of drugs should include factors such as the good or bad performance of the drugs themselves. The performance price should be higher than the price of large infusion of balanced glass bottles. The price of large infusion of plastic bottles and infusion bags should be reduced and then reduced

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